Opioids: The poison behind the high

The Middle East and Central Asia have been major opium production centres for millennia but the growing legitimate and illegitimate use of these powerful drugs is also causing big problems

Opioids: The poison behind the high

If you were to cut an opium poppy seed pod, it would exude a latex or creamy emulsion from the seed capsules. If you were to dry that latex, you would be on your way to producing heroin and other pain-relieving synthetic opioids. You would also be doing what humans have done for at least 7,000 years.

Today, the drugs that derive from the poppy create an industry worth around $68bn. Owing to where the plant grows, the Middle East is in the thick of it. Until 2019, more than 80% of the world’s opium came from Afghanistan. Iran is also a big producer.

Opioid drugs are used legitimately (in medicine) and illegitimately. Users often turn to crime to pay for their addiction. This has major economic, societal, and health impacts. The global cost of the problem is estimated to be a staggering $1tn. This, of course, warrants a more detailed look.

Medicine and abuse

Medicinal opioids are usually prescribed for severe pain relief. When used correctly under medical supervision, they can greatly improve patients’ quality of life. Morphine, the most famous, is often used in palliative medicine to give terminally ill patients more comfortable end-of-life care. Oxycodone and hydrocodone are often prescribed to manage acute pain following surgery or severe injury.

Despite their benefits, opioids are highly addictive. Misuse occurs when people take these drugs without a prescription, in higher doses than prescribed, or use illicit opioids like heroin, which is manufactured from morphine. This misuse can lead to dependence, overdose, and death, creating a public health crisis.

Until 2019, more than 80% of the world's opium came from Afghanistan. Iran is also a big producer.

Opioids' addictive nature stems from their ability to produce euphoria in addition to pain relief. This euphoria can lead to recreational use, which quickly spirals into dependency. The body builds a tolerance to the drug, requiring higher doses to achieve the same effect. This increases the risk of overdose, which causes fatalities.

The World Health Organisation estimated that in 2019, around 125,000 people died globally from opioid overdose. During and after the COVID-19 pandemic, opioid addiction increased, leading to record deaths and a higher economic burden.

Market dilemma

The market for both legal and illegal opioids is vast. In 2020, the global analgesics (painkillers) market was valued at around $26bn, with opioids making up a significant portion. The legal market comprises pharmaceuticals prescribed for legitimate medical use, but the illegal opioid market—including heroin and synthetic opioids like fentanyl—adds an unquantifiable amount to this total.

Fentanyl has been a particular driver of the current opioid crisis due to its potency and the ease with which it can be manufactured and distributed illicitly. Yet, in many places, including Asia and the Middle East, the opioid market is expanding.

Until recently, Afghanistan produced four-fifths of the world's opium, but in August 2021, the Taliban—an Islamist fundamentalist group—took control of the country, and in April 2022, they announced a ban on poppy cultivation. By 2023, this had had a dramatic effect. Opium poppy cultivation and opium production had declined by 95% in Afghanistan, from 6,200 tonnes in 2022 to 333 tonnes in 2023.

Lina Jaradat

By August 2023, the monthly farm-gate price of a kilogramme of dried opium was $408—nearly five times more than before the Taliban takeover. The Taliban ban was driven by ideology, but it can be a double-edged sword as farmers suffer and other countries replace the lost Afghan supply to meet the global demand.

Economic burden

The medicinal opioid market is growing in nations with advanced healthcare systems, like Egypt, Saudi Arabia, and the UAE, while the illegal market remains substantial. In these countries, there has been an increase in the prescription of opioids for pain management, which also increases the risk of diversion and abuse.

The economic impact of opioid abuse is enormous. This covers health, productivity, criminal justice, and social welfare. The healthcare costs include addiction treatment, emergency room visits, and long-term care.

In the United States, the overall cost stemming from opioid abuse during the pandemic was estimated at around $1.5tn. Yet there are non-financial costs, too, with families and communities often devastated by addiction and its consequences.

In the Middle East, opioid abuse also imposes significant economic burdens. Healthcare systems are strained by the need to treat addiction and related health issues, while police spend considerable resources combating the illegal drug trade.

In Egypt, millions of dollars are spent every year on addiction, including through public health campaigns, rehabilitation centres, and treatments. Egypt's economy can ill afford any increase in this problem.

The global cost of the opioid problem is estimated to be a staggering $1tn

Curing the problem

Controlling a trade worth many billions of dollars will never be easy, and a comprehensive strategy is needed. Part of this is enhanced prescription monitoring programmes. These can track and regulate opioid prescriptions across different healthcare providers and pharmacies, thus reducing the risk of misuse, such as when patients get multiple prescriptions from different sources.

Strict regulatory policies on the sale and distribution of opioids, including tighter controls on pharmaceutical companies and healthcare providers, can prevent over-prescription and illicit sales, limit the number of opioids that can be prescribed, ensure mandatory training for providers, and penalise violators.

Public awareness campaigns are vital to educate about the dangers of opioid misuse and the signs of addiction. This should be incorporated into school and university curricula, ensuring that young people are better informed about the risks and consequences of misuse before encountering these substances.

Families also have a crucial role to play, with open communication within the home. By discussing the risks of opioids and setting a positive example, parents can help their children make informed decisions and avoid the pitfalls of addiction.

Expanding access to addiction treatment and rehabilitation, including medication-assisted treatment (MAT), can help those struggling with opioid dependence to recover and reintegrate into society. MAT, with counselling and behavioural therapy, is considered the gold standard for treating opioid addiction.

In the Middle East, healthcare systems are strained from treating opioid addiction and related health issues

Prescribing change

Robust support systems for those in recovery—such as counselling, job training, and social services—can help prevent relapse while enhancing police capabilities to combat the illegal opioid trade; better training and equipment can stem the flow of illicit opioids, such as by detecting and intercepting shipments.

This is a cross-border problem, so collaborating with international bodies and neighbouring countries is essential. Detailed studies on the economic impact of opioid abuse in the Middle East can highlight the urgency of the issue and justify the allocation of resources to combat it.

Research can also help identify the most effective strategies for preventing and treating opioid addiction, ensuring that resources are used in the most impactful ways. By implementing these strategies, the Middle East can control the opioid trade, mitigate the economic burden of addiction, and protect public health.

Balancing the legitimate medical use of opioids (to relieve pain) with measures to prevent their misuse is crucial for ensuring citizens' well-being and for creating a safer and healthier society for all.

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