Each character deals with their own kind of loss.
Syd deals with the loss of her mother as a child and the resulting shakiness in her relationship with her father, on top of her attempts to justify her career choices.
Meanwhile, Richie, a wandering man in his mid-40s, struggles with a loss of passion and purpose. The world changes around him at a dizzying pace, and he feels constrained, like his actions and words are being controlled. He senses that everyone is conspiring to create this new reality without his knowledge.
Carmy, in the meantime, is stuck in a different kind of hell.
In a monologue from episode eight of season one, he talks about his relationship with brother Mikey and how they developed a strong emotional bond through food.
White gave an excellent performance that practically transformed him from a weary man into the younger brother he once was, eyes shining like a child while describing Mikey's absolute confidence and immense charisma, believing he had all the solutions to the world's problems.
(White won his first Golden Globe for his performance, as well as earning his first Emmy nomination.)
It's through this scene that we discover the extent of Carmy's anguish over the idea of losing his brother. On the one hand, he sees that the only salvation for him is to save this doomed restaurant because they had once vowed to open a restaurant together.
On the other hand, Carmy completely blames himself for his brother's suicide because if he hadn't been so preoccupied with his job, he would have known about his addiction and could have saved him from his demons.
Poetically, it feels like the salvation Carmy seeks lies in digging himself deeper and deeper into this hellhole.
The series refuses to embrace the cliché of "time heals all wounds". Instead, it deals with the theme of death and loss in a more realistic way. It conveys the message that time facilitates acceptance and living with these wounds, rather than healing from them.
So far, Carmy's journey seems far from over. He still doesn't trust the momentary happiness he occasionally feels and has a hard time accepting any form of praise.
Inside, he struggles with the thought of his brother's suicide. He doesn't find himself funny, he doesn't possess an attractive youthful charm, and he doesn't bother looking for solutions to these feelings because all the solutions disappeared the moment he lost his brother.
Carmy's wounds are far from sewn shut at the end of the second season, and they likely won't be healed by the end of his story, either.